Genesis Global Group
Integrated Analytical Solutions, Inc.

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Integrated Analytical Solutions, Inc. is a proud member of Genesis Drug Discovery & Development (GD3), a fully integrated CRO providing services to support drug discovery programs of our clients from target discovery through IND filing and managing Phase I-III clinical trials.

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Metabolite Identification

As selected compounds show promise it may be necessary to further characterize the overall suitability of their bioanalytical methods. We offer various levels of bioanalytical method qualification to provide you with the assurance that a method has the desired level of accuracy, precision, sensitivity and stability for a particular stage of development. At this level, bioanalytical methods for lead candidates and critical biomarkers are further optimized and qualified to support pivotal PK studies, dose range-finding, toxicokinetic, and tissue distribution studies.IAS offers expert capabilities for identifying metabolites that may cause unintended side effects. The data acquired from these experiments is interpreted and scrutinized by our most experienced scientific staff. You can expect very detailed reports containing elucidated/proposed metabolite structures as well as sites of modification on the precursor molecule.

Metabolite ID Capabilities

  • In Vitro: analysis performed in samples from concentrated in vitro reactions
  • In Vivo: analysis performed in selected matrices from PK, Tox and Clinical studies
Metabolite Identification Illustration